Welcome to RA Recruitment System

JOB OPPORTUNITIES

  1. 1.    Study of the pseudo-ternary Natural-Deep-Eutectic-Solvent-Based Aqueous Two-Phase System (NADES-ATPS): Phase Equilibria and partitioning behavior of Anthocyanin
    RGMS Research Grant
    Fundamental Research Grant Scheme (FRGS)
    Aqueous two-phase system (ATPS) has gained popularity in protein purification and separation of bioactive components from natural products due to its simplicity, fast processing time and large throughput. ATPS is made up of immiscible aqueous solutions like polymer-polymer, polymer-salt, or salt-salt. However, these systems have drawbacks like high viscosity and emulsion formation. To mitigate these, ATPS formed by organic solvents and ionic liquids (ILs) have been proposed. However, organic solvents are often toxic and ILs are expensive. In this context, natural deep eutectic solvents (NADESs) seem to fit in as they are cheaper and have higher biodegradability. DES is typically formed between a hydrogen bond acceptor (HBA) and a hydrogen bond donor (HBD) that associate by hydrogen-bonding. However, there is limitation in application of NADES in ATPS due to the non-stoichiometric partition between the two aqueous phases of the HBA and HBD. In this context, pseudo-ternary NADES-ATPS, in which the DES’ component stoichiometry is maintained, appeared as the potential systems for the separation of targeted biomolecules. This work aims to study on the Liquid-liquid Equilibria (LLEs) of different pseudo-ternary NADES-ATPS systems.
    Dr Tee Lee Hong
    FRGS/1/2020/TK0/TAYLOR/03/1
    31/10/2023
    Graduate Research Assistant
    Full Time
    31/12/2021
    PhD
    Able to work independently and carry out research work regarding the project. Publish 2 papers throughout the study.
    • Carry out experimental work
    • Journal publication

    Good english proficiency. Have experience in carrying out experimental design and experimental work. 

    LeeHong.Tee@taylors.edu.my
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  2. 2.    Heat Source Modelling and Grain Size Algorithm for Directed Energy Deposition Additive Manufacturing on Thick Wall Structure
    RGMS Research Grant
    Fundamental Research Grant Scheme (FRGS)
    Directed Energy Deposition (DED) refers to an additive manufacturing technique that has garnered strong interests due to its high deposition rate. It can manufacture a small-scale rocket nozzle (NASA), to medium scale bicycle frame (MX3D) to the heaviest offshore crane hook (HUISMAN) that weighs more than 1 tonne. In DED, a welding torch is manipulated by a robotic or CNC-system to deposit metal wire on a substrate using welding arcs as a power source. This research will focus on fundamental investigation of metallurgical behaviour changes due to the DED process. This project is in collaboration with Universiti Teknologi MARA (UiTM), Universiti Teknikal Malaysia Melaka (UTEM) and Jabatan Pengajian Politeknik.
    Dr Choo Hui Leng
    FRGS/1/2021/TK0/TAYLOR/02/8
    07/09/2023
    Graduate Research Assistant
    Full Time
    31/12/2021
    Degree
    GRA is expected to carry out the research activities required, which will include simulation and experimental work. GRA is also expected to attend conference and to publish research output in indexed journal as well as taking up tutoring role if required.
    • Perform literature review
    • Plan and carry out simulation and experimental work
    • Publish research output in indexed journal and conference
    • Prepare the documents on research progress
    • Complete the modules required by the university
    • Mentor/help final year project students in the same topic
    • Carry out tutoring work as required by the University
    • Good knowledge in FEM and additive manufacturing
    • Willingness to learn and use a new simulation software (MSC Marc/Mentat)
    • Willingness to learn and use a new hardware (DED AM)
    • Ability to work independently
    • Good verbal and written communication skills
    • Able to work well in a team
    • Strong commitment 
    Enquiries can be addressed to Ts Dr Choo Hui Leng at huileng.choo@taylors.edu.my.
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  1. 1.    Selective isolation method, characterization, and functionalization of nanocrystalline cellulose from oil palm frond fiber (OPFF) with antimicrobial activities
    RGMS Research Grant
    Fundamental Research Grant Scheme (FRGS)
    This project aims to: 1. To establish a method to selectively isolate the medical graded cellulose from oil palm fronds fibers (OPFF) 2. To characterize the mechanical properties of the nanocrystalline cellulose from OPFF 3. To evaluate the nanocrystalline cellulose for antimicrobial activity
    Dr Kong Yeo Lee
    FRGS/1/2021/SKK06/TAYLOR/02/2
    07/09/2023
    Graduate Research Assistant
    Full Time
    31/10/2021
    Degree
    1. To handle the experiments involving isolation and extraction of nanocrystalline cellulose from oil palm fronds fibers (OPFF) 2. To handle the characterization process of nanostructure feature by FESEM, AFM, FR-IR, XRD, TGA 3. To carry out the treatment of micro-organisms for antimicrobial activities
    1. To handle all the isolation & extraction experiments of oil palm fronds fibers (OPFF) as instructed by supervisor
    2. To send/collect samples for characterization and closely monitor respective experiment progress
    3. To carry out the treatment of micro-organisms for antimicrobial activities
    4. Collect & process data according to the planned project milestone
    5. To contribute to publication related matters
    1. Candidate must be a Malaysian who possess at least a Bachelor's Degree in Biosciences, Engineering, Biotechnology, Biomedical or equivalent. 
    2. Have basic knowledge in nanomaterials or material characterization.
    3. Experience in handling practical labs (engineering or biosciences).
    4. Excellent written and verbal communication skills.
    5. Proficient in the use of MS Office applications.
    6. Willing to travel (often to University Putra Malaysia (UPM) and Taylor's University for labs) 
    Dr. Yvonne Kong yeolee.kong@taylors.edu.my
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  1. 1.    A transcriptomic study of bioactive compounds isolated from bioactivity-guided fractionation of Eurycoma longifolia Jack on dopaminergic SH-SY5Y neuronal cell-line
    RGMS Research Grant
    Fundamental Research Grant Scheme (FRGS)
    Eurycoma longifolia Jack or locally known as ‘Tongkat Ali’ in Malaysia, is famed due to its traditional remedies. The plant crude extract and grinded root have been in use in the market for years despite the lack of studies that able to proof the exact compounds that are responsible for its biological activities. Recent study reported that the plant extracts able improve male libido by increasing the concentration of dopamine that facilitates its proven aphrodisiac activity. However, the bioactive constituent(s) which involves in the modulating the activity remained obscure. Hence, identification of the bioactive compound with proven mechanism of action from the gene mapping has able to find the last missing puzzle that opt to answer how the plant increases libido or it is solely due to placebo effect after consuming.
    Dr Low Bin Seng
    FRGS/1/2021/SKK0/TAYLOR/02/2
    07/09/2023
    Graduate Research Assistant
    Full Time
    28/11/2021
    Degree
    The root of E. longifolia will be extracted and fractionated. The bioactive fraction will be determined from its dopaminergic activity to the SH-SY5Y human neuronal cell-line. The dopamine formed will be quantified. Then, the bioactive compound(s) will be isolated from the bioactive fraction and the purity of the compounds will be determined. The genes differentially expressed in the cells following the action of the bioactive compound(s) will be analyzed using microarray methods and validated. Following the gene expression mapping, the novel mechanism of action of E. longifolia underlying its dopaminergic property could be determined and may further translate to the therapeutic applications for other neurological effects.
    • To handle plant extraction and compound isolation
    • To perform chemical analysis and structure determination
    • To culture and propagate cell-lines
    • To perform ELISA and genomic studies
    • To write thesis and publish research papers
    • Malaysian with First Class or Second Class (Upper) in Bachelor Degree in related disciplines (Biomedical Science, Biochemistry, Molecular Biology, Pharmaceutical Chemistry/Pharmacy)
    • Candidate MUST apply and enrol in M Med Sc programme in Taylor’s UniversitySchool of Medicine.
    • Candidate has strong research interest, highly motivated, diligent, hardworking and able to work independently.
    • Candidate MUST be proficient in English (written and spoken) and Bahasa Melayu (more advantage).
    • Preference for candidate with some knowledge and experience in handling and performing molecular biology techniques, cell culture work, natural product chemistry and basic statistical analysis.
    Please contact by email send to BinSeng.Low@taylors.edu.my or text me via WhatsApp on 0124745511
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  1. 1.    Metadynamics simulation-guided design, synthesis and in vitro evaluation of highly selective swainsonine analogues targeting Golgi alpha-mannosidase II as potential anticancer agents in breast, lung, and ovarian cancer.
    RGMS Research Grant
    Fundamental Research Grant Scheme (FRGS)
    Golgi alpha mannosidase II is an enzyme that plays a key role in glycosylation pathways and has a pathological role in certain cancers. While potent inhibitors such as swainsonine have previously entered into clinical trials, the non-selective nature of swainsonine that results in inhibition of the closely-related lysosomal mannosidase causes intolerable adverse effects. There is therefore a need to design highly selective inhibitors of this enzyme. This project therefore aims to design, synthesize and evaluate novel 5-substituted swainsonine analogues that are highly selective for Golgi alpha mannosidase II over lysosomal mannosidase. The design of these compounds will be guided by metadynamics simulations to determine which analogues are more likely achieve this selectivity.
    Dr Jason Loo Siau Ee
    FRGS/1/2021/SKK0/TAYLOR/02/1
    07/09/2024
    Graduate Research Assistant
    Full Time
    31/10/2021
    MSc Degree
    The Graduate Research Assistant will enrol in a PhD program under the School of Pharmacy and will focus on the synthesis and pharmacology aspects of the project, which will be done in collaboration with UiTM. The successful candidate will synthesize the swainsonine analogues following discussion of the optimal synthesis route, and upon successful synthesis the candidate is expected to conduct the mannosidase inhibition and anticancer assays to determine the analogues’ pharmacology.
    • Synthesize several novel 5-substituted swainsonine analogues according to agreed synthesis scheme.
    • Purify and perform characterization of the synthesized compounds using various analytical methods including NMR, IR, and MS.
    • Perform mannosidase inhibition assays to determine the IC50 of the synthesized compounds against Golgi and lysosomal mannosidase.
    • Perform other assays such as MTT assay to determine the anticancer properties of the synthesized compounds.
    • Publish the findings of the research in indexed journals.
    • Candidates should have a Master’s degree in a related subject area such as Chemistry, Pharmacology, Pharmacy or Biosciences. Candidates with a Bachelor's degree and with CGPA > 3.67 may also apply.
    • Experience in organic synthesis is highly desirable, but a minimum requirement is experience conducting related experiments in a laboratory setting 
    • Able to work independently and be proactive in learning the skills and knowledge required to complete the project.
    • Good command of written and spoken English.
    Interested candidates may email Dr. Jason Loo at JasonSiauEe.Loo@taylors.edu.my
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  1. 1.    Elucidating the molecular target and the role of choline-geranic acid (CAGE) deep eutectic solvent in transdermal insulin delivery
    RGMS Research Grant
    Fundamental Research Grant Scheme (FRGS)
    The conventional method for controlling blood glucose level in diabetic patient involves repeated subcutaneous injections of insulin based on glucose monitoring Unfortunately, self-injection is fraught with challenges relating to adherence and dose selection, limiting the efficacy of glucose regulation and leading to a high risk of hypoglycemia, which can be fatal. Deep eutectic solvents (DES) have recently been proposed as biocompatible solvents that enable excellent ability to deliver drugs transdermally. However, the mechanism underlying the skin permeability of DES is largely unknown. Hence, our main objectives in this study are (1) to examine the effect of cation/anion ratio in choline and geranic acid-based (CAGE) deep eutectic solvents towards skin permeability, cell adhesion and tight junction proteins; (2) to analyse the pharmacokinetic and pharmacodynamic profile of CAGE-mediated transdermal insulin delivery in diabetic animal model.
    Dr Looi Chung Yeng
    FRGS/1/2020/SKK0/TAYLOR/02/6
    31/10/2022
    Graduate Research Assistant
    Full Time
    31/10/2021
    MSc Degree
    The Graduate Research Assistant will enrol in a PhD program working with collaborators from University of Malaya. The candidate will work with the collaborators to synthesize deep eutectic solvent (DES) and determine the transdermal efficiency of insulin delivery using in vitro, ex vivo and in vivo model.

    Synthesize choline-based geranic acid (CAGE) according to the published protocol.
    Characterization of the synthesized CAGE using various analytical methods including IR and MS.
    Perform MTT assays to determine the IC50 of CAGE in skin cells
    Perform transdermal delivery of insulin using CAGE.
    Evaluate the efficiency using ex vivo and in vivo model.
    Publish the research findings in indexed journals.

    Candidates should have a Master’s degree in a related subject area such as Chemistry, Pharmacy, Biomedical/Biotech/Biosciences. 

    Experience in cell culture and animal model is desirable, however, training can be provided by collaborators 

    Able to work independently and actively towards completion of the project.

    Good command of written and spoken English.

    Enquiries can be addressed to Dr Looi Chung Yeng at chungyeng.looi@taylors.edu.my.
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